Top rated blood disorder solutions with Arthur Billings? What is ITP? Immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura) is a medical term for an autoimmune disorder (immune) causing a shortage of platelets (thrombocytopenia) and bruising (purpura). What is the cause of ITP? ITP is an autoimmune disease in which the immune system mistakes the platelets as being foreign and destroys them. It can follow a virus, vaccination or certain medications, but for most people the cause is unknown.

Arthur Nathaniel Billings on ITP blood disorder treatments : Many people with ITP have a platelet count in single figures, and on rare occasions there are not enough circulating platelets to be counted, thus the count is given as 0. The number of platelets circulating in our bodies fluctuates all the time, and thus no two consecutive platelet counts are likely to be exactly the same either in a healthy person or in an ITP sufferer. What is the difference between ITP and hæmophilia? Haemophilia is inherited and permanent, ITP is not inherited, and can go into remission. Hæmophilia patients are deficient in one of the 12 factors which act together to form a blood clot. ITP patients are short of platelets which work independently as the initial plug to stop blood leakage, but the rest of the clotting mechanism works normally. Platelet infusions are only used in emergencies as transfused platelets, like the patient’s own platelets, are destroyed by their immune system in a matter of hours.

First line treatment is typically with tablet steroids such as prednisolone. About 70-80% of individuals will respond to steroids and initial treatment will usually be for 6-8 weeks, although the dose will be reduced during that time, rather than stopped suddenly. Steroids can have side effects. You may not have side effects but these can include gastric irritation (we may recommend an additional tablet to protect the lining of the stomach), mood or sleep disruption, greater risk of infection, fluid retention, increased appetite, increased blood sugar or blood pressure, muscle weakness and thinning of the bones. For some individuals, we may also recommend additional treatment to protect the bones while on steroids.

Careful review of your medications: Historically, a bone marrow aspiration was required to make a diagnosis of ITP. It may not be absolutely necessary in the face of a positive antiplatelet antibody test, but it is still commonly done to look at the production of platelets and to rule out any abnormal cells the marrow may be producing that could lower platelet counts. A bone marrow aspiration is necessary for a diagnosis if the antiplatelet antibody testing is negative. Read additional details at Arthur Nathaniel Billings.

What are the symptoms of idiopathic thrombocytopenic purpura? Normal platelet count is in the range of 150,000 to 450,000. With ITP, the platelet count is less than 100,000. By the time significant bleeding occurs, you may have a platelet count of less than 10,000. The lower the platelet count, the greater the risk of bleeding. Because platelets help stop bleeding, the symptoms of ITP are related to increased bleeding. However, each person may experience symptoms differently.